The two-wire interface consists of two signal lines named SDA (serial data) and SCL (serial clock) (plus a ground line, of course). All devices participating in the bus are connected together, using open-drain driver circuitry, so the wires must be terminated using appropriate pullup resistors. The pullups must be small enough to recharge the line capacity in short enough time compared to the desired maximal clock frequency, yet large enough so all drivers will not be overloaded. There are formulas in the datasheet that help selecting the pullups.