本文针对多光谱图像配准中不同光谱图像间存在较大的灰度差异、同一景物在不同波段表现的特征也各不相同等问题，提出了基于互信息相似性测度的多光谱图像配准算法。-In this paper, multi-spectral image registration between different spectral image there is a big difference in gray scale, the same scene in different bands performance characteristics are different questions, we present a similarity measure based on mutual information of multi-spectral image registration algorithm .