In this demo, I use the EM algorithm with a Rauch-Tung-Striebel smoother and an M step, which I ve recently derived, to train a two-layer perceptron, so as to classify medical data (kindly provided by Steve Roberts and Will Penny from EE, Imperial College). The data and simulations are described in: Nando de Freitas, Mahesan Niranjan and Andrew Gee Nonlinear State Space Estimation with Neural Networks and the EM algorithm After downloading the file, type \"tar -xf EMdemo.tar\" to uncompress it. This creates the directory EMdemo containing the required m files. Go to this directory, load matlab5 and type \"EMtremor\". The figures will then show you the simulation results, including ROC curves, likelihood plots, decision boundaries with error bars, etc. WARNING: Do make sure that you monitor the log-likelihood and check that it is increasing. Due to numerical errors, it might show glitches for some data sets.