尺度不变特征转换(Scale-invariant feature transform或SIFT)是一种电脑视觉的算法用来侦测与描述影像中的局部性特征，它在空间尺度中寻找极值点，并提取出其位置、尺度、旋转不变量，此算法由 David Lowe在1999年所发表，2004年完善总结。(SIFT predicts whether an amino acid substitution affects protein function. SIFT prediction is based on the degree of conservation of amino acid residues in sequence alignments derived from closely related sequences, collected through PSI-BLAST. SIFT can be applied to naturally occurring nonsynonymous polymorphisms or laboratory-induced missense mutations.)