摘要：针对传统方法优化药代动力学参数时精度不高的缺陷，将Hooke-Jeeves 算法与人口迁移算法有机融 合，使两者取长补短，既提高了算法的精度，又加快了算法的收敛速度。将混合人口迁移算法用于血管外给药 二室模型参数优化的实验之中，不仅比传统的残数法效果要好，而且比Hooke-Jeeves 算法或人口迁移算法更 优，精度更高。多次实验表明：算法具有良好的可靠性和稳定性，是一种较好的解决药代动力学参数的方法。

hooke算法的自我编写的小小的程序能够用来计算问题的最优值-hooke

The elapsed time of Nelder and Mead simplex method seems to be larger than Hooke and Jeeves method but, it reached the solution in just 2 iterations which is remarkably less than the previous method. From Tables 1 and 2 it can be said that the optimi